Natural coagulation inhibitors in liver diseases

Natural Coagulation Inhibitors and Inflammation.

mostasis and inflammation are closely related processes. It is recognized that the activation of hemostasis fosters, to a certain extent, inflammation and that inflammation, in turn, activates the hemostasis system. These interrelationships are best illustrated in sepsis, were microorganisms or their release products, most notably cytokines, causing inflammation, activate the hemostasis system....

Natural coagulation inhibitors and active protein c resistance in preeclampsia

INTRODUCTION The etiology of preeclampsia is not fully established. A few studies have shown a relationship between natural coagulation inhibitors and preeclampsia. OBJECTIVES The purpose of this study was to investigate the status of natural coagulation inhibitors and active protein C resistance (APC-R) in preeclampsia. PATIENTS AND METHODS We studied 70 women with preeclampsia recruited c...

Coagulation inhibitors in inflammation.

Coagulation is triggered by inflammatory mediators in a number of ways. However, to prevent unwanted clot formation, several natural anticoagulant mechanisms exist, such as the antithrombin-heparin mechanism, the tissue factor pathway inhibitor mechanism and the protein C anticoagulant pathway. This review examines the ways in which these pathways are down-regulated by inflammation, thus limiti...

Coagulation in Liver Disease

Inhibitors in congenital coagulation disorders.

The development of inhibitory 'allo' antibodies to a deficient coagulation factor is arguably now the most severe and important complication of clotting factor concentrate exposure in haemophilia and other congenital coagulation disorders. Furthermore, development of an inhibitor to the factor VIII or factor IX transgene product remains a significant concern in gene therapy protocols for haemop...